منابع مشابه
Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII.
Human blood coagulation Factor XI was purified in 20% yield from plasma by ion exchange chromatography. The specific clotting activity of purified Factor XI was 250 & 20 units/mg implying that its concentration in normal titrated human plasma is 4 pg/ml. The purified Factor XI in its precursor form gave a single protein band on polyacrylamide gels in the presence of sodium dodecyl sulfate with ...
متن کاملFactor XI: purification from porcine plasma by affinity chromatography and some properties of factor XI and activated factor XI.
Porcine factor XI and activated factor XI were purified by the introduction of affinity chromatography on high molecular mass kininogen. On the affinity chromatography, it was observed that high affinity exists between porcine factor XI and high molecular mass kininogen. In the preparation, however, factor XII, plasma prekallikrein and high molecular mass kininogen were not detected. The factor...
متن کاملPseudo-factor-XI deficiency: effect of an inhibitor of factor XI adsorption to surface.
Recently we have described a normal plasma activity that modulates contact activation by inhibiting adsorption of factor XI to activating surfaces. Here we report the first identified case in which a patient has abnormal clotting tests due to an excess of a similar activity. The patient's plasma had a prolonged partial thromboplastin time and low apparent factor XI assay. His plasma prolonged t...
متن کاملActivated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.
Activation of coagulation factor XI (FXI) may play a role in hemostasis. The primary substrate of activated FXI (FXIa) is FIX, leading to FX activation (FXa) and thrombin generation. However, recent studies suggest the hemostatic role of FXI may not be restricted to the activation of FIX. We explored whether FXI could interact with and inhibit the activity of tissue factor pathway inhibitor (TF...
متن کاملPlatelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI
INTRODUCTION Factor (F) XI supports both normal human hemostasis and pathological thrombosis. Activated FXI (FXIa) promotes thrombin generation by enzymatic activation of FXI, FIX, FX, and FV, and inactivation of alpha tissue factor pathway inhibitor (TFPIα), in vitro. Some of these reactions are now known to be enhanced by short-chain polyphosphates (SCP) derived from activated platelets. Thes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1988
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.19.100